In this context, it is interesting to mention that physapubescin (from Physariumpubescens) has been shown to react with protein thiol-nucleophiles, down-regulating the expression of HIFs and selectively up-regulating the expression of CHOP and DR5 leading to apoptosis in VHL-null RCC [59]. Here, TNFRSF10B is linked to renal cell carcinoma.