In light of a recent study showing RIPK3-MLKL necroptotic pathway induction by ASC-NLRP3 inflammasome independent of caspase-1 [45], our result suggests a possibility of ASC-NLRP3 inflammasome not only inducing pyroptosis during RSV infection but partially contributing to necroptosis induction during infection via caspase-1 independent mechanism. This evidence concerns the gene NLRP3 and infection.