Mouse models, where each mouse line carries and expresses a different human SP-A1 or SP-A2 variant or both, showed a differential impact on the bronchoalveolar lavage proteome [118], as well as the alveolar macrophage proteome [121,124], miRNome [117,119], and gene expression [132] under baseline conditions and in response to ozone-induced oxidative stress (OxS) or infection, and these responses were sex-specific. This evidence concerns the gene SFTPA2 and infection.