PMS2 and endometrial cancer: According to the largest published series, the mutation detection rate (positive predictive value, PPV) of an immunohistochemistry staining of MMR proteins in order to identify LS associated endometrial cancers is 46% if all unselected endometrial cancer cases below age 60 are analyzed, IHC is eventful and methylation as a cause of MLH1/PMS2 loss can be excluded.