BRCA1 and endometrial cancer: Evidence has been presented that BRCA1 variant carriers after risk-reducing salpingo-oophorectomy may have an increased risk of the more aggressive but rarer serous/serous-like endometrial cancers, though no significant risk of the endometrioid subtype cancer [84], and that these BRCA1-associated endometrial cancers are associated with an unfavorable outcome [85].