To investigate the potential effect of NRF2 on fibrotic toxicity of HK-2 cells caused by HA, we used the NRF2 activator SFN (0–20 μM) to reverse HA-induced NRF2 protein downregulation and then measured the changes in the expression of key genes related to renal fibrosis. The gene discussed is NFE2L2; the disease is renal fibrosis.