Pathways associated with calcium signalling and cardiomyopathy (Table 1) involved intracellular signalling enzymes including integrins, adenylate cyclases 4 and 9, ATPases, and calcium channels, and indeed calcium homeostasis may reflect aberrant osteoblastic differentiation during osteosarcoma carcinogenesis [116]. Here, ADCY4 is linked to cardiomyopathy.