Furthermore, four different variants in NOD2 gene (NM_022162.2:c.2230C > T (p.Arg744Trp), NM_022162.2:c.2127G > A (p.Trp709*), NM_022162.2:c.676_691del (p.Arg227fs*145) and NC_000016.9(NM_022162.2):c.2883‐2A > G) were also observed in FMF cases. This evidence concerns the gene NOD2 and familial Mediterranean fever.