We observed that 10 out of the 50 FMF cases had variants in genes linked with familial haemophagocytic lymphohistiocytosis (FHL), with PRF1 NM_005041.4:c.272C > T (p.Ala91Val), NM_005041.4:c.1153C > T (p.Arg385Trp) and STXBP2 NM_006949.3:c.1034C > T (p.Thr345Met) variants present in 3 patients each, while variants in other known FHL‐associated genes (RAB27A and UNC13D) were present in one FMF case each. The gene discussed is PRF1; the disease is hemophagocytic syndrome.