The top candidate variant identified in this analysis was IFNAR2 NM_207585.2:c.611C > G: (p.Thr204Arg), which was present in 14% of FMF cases from all subcategories (with 0, 1 and 2 MEFV mutations) and which is involved in type 1 interferon signalling. This evidence concerns the gene MEFV and familial Mediterranean fever.