IL1B and Down syndrome: Six broad categories of AID have been proposed based on the genetic defect in different component of the immune system: (a) IL‐1beta activation disorders (inflammasomopathies), (b) NF‐kB activation syndromes, (c) protein misfolding disorders, (d) complement regulatory diseases, (e) disturbances in cytokine signalling and (f) macrophage activation syndromes.37