Six broad categories of AID have been proposed based on the genetic defect in different component of the immune system: (a) IL‐1beta activation disorders (inflammasomopathies), (b) NF‐kB activation syndromes, (c) protein misfolding disorders, (d) complement regulatory diseases, (e) disturbances in cytokine signalling and (f) macrophage activation syndromes.37 The gene discussed is IL1B; the disease is macrophage activation syndrome.