While the current study showed that FMF patients carried a large spectrum of variants in several inflammatory genes, certain variants seem to be quite prevalent in patients carrying a single or no mutation in MEFV gene including variants in the 4 genes (PRF1, STXBP2, RAB27A and UNC13D) associated with FHL and the novel variant that we have discovered in the IL1RL1 gene. This evidence concerns the gene IL1RL1 and familial Mediterranean fever.