Although this current study, showing the presence of many rare variants in genes associated with auto‐inflammatory disorders and a novel variant (a 2.1‐Kb deletion) in exon 11 of IL1RL1 gene (NM_016232) in atypical FMF patients (carrying a single or no mutation in MEFV), supports the multigenic inheritance model of FMF, a large‐scale typing in Lebanese FMF patients is needed. The gene discussed is IL1RL1; the disease is familial Mediterranean fever.