CD8A and neoplasm: Co-stimulation determines transcriptional regulation of IFNγ in tumor-infiltrating T cells [118], and in its absence, enforces post-transcriptional silencing of IFNγ in anergic self-reactive T cells [119], perhaps underscoring the blunted transcriptional (Fig 9B) and translational CD8 T cell IFNγ response to parasite-infected Nlrp3-/- BMDMs (Fig 8).