IFNG and infection: Whereas the percentage of early activated CD69+ T-GREAT cells in response to ME49 and MAS infections was slightly decreased to Nlrp3-/- compared to WT BMDMs (Fig 9A), IFNγ transcript levels in the activated CD69+ population dropped by 50–70% (Fig 9B), suggesting NLPR3 induces a macrophage-derived signal required for IFNγ transcription in activated CD8 T cells.