In light of these findings, we determined whether the T allele and/or reduced SIRPγ expression is an underlying feature in two T-cell mediated autoimmune diseases, including relapsing remitting multiple sclerosis (RRMS) and type 1 diabetes (T1D), and if this can have pathogenic consequences, presumably due to exaggerated effector responses from SIRPγ low T-cells. The gene discussed is SIRPG; the disease is autoimmune disease.