TNF and histiocytic sarcoma: With regard to the magnitude of the cytokine response in HS skin, we observed significant responses for stimulation of type II IFN (i.e., IFN-γ; P = 5.9 × 10–5) and IL-36 (P = 9.3 × 10–4) in HS lesional skin, whereas the effect of Th2 response (i.e., IL-4), IL-17A, or TNF stimulation was absent in HS skin (Figure 1C).