MAP3K5 and rheumatoid arthritis: By analogy to other types of autoimmune disease, earlier studies also support the key role MIR17HG cluster play in controlling the inflammatory process and disease activity through regulation of the “Apoptosis Signal‐Regulating Kinase 1 (ASK1) signalosome,” a central actor in the inflammatory pathways activated during rheumatoid arthritis.33, 34