No obvious hindlimb weakness or ataxia phenotypes were observed in 5‐month‐old and 16‐month‐old Tmem106b+/−Grn−/− and Tmem106b−/−Grn+/− mice (our unpublished observations), suggesting that total loss of both PGRN and TMEM106B is required for the development of these behavioral phenotypes. This evidence concerns the gene GRN and cerebellar ataxia.