TMEM106B and early-onset autosomal dominant Alzheimer disease: It has been proposed that TMEM106B functions as a risk factor for FTLD in a similar manner as APOE for Alzheimer's disease (Wood, 2010; Cruchaga et al, 2011; van der Zee & Van Broeckhoven, 2011; Deming & Cruchaga, 2014; Jain & Chen‐Plotkin, 2018).