Therefore, it is plausible to hypothesize that DPP4 may play a role also in human NAFLD and, in consideration of the characteristics of this enzyme, which is cleaved and released in the bloodstream in relation to its tissue expression, its circulating concentration and activity may reflect the severity of liver impairment in presence of NAFLD and NASH. The gene discussed is DPP4; the disease is metabolic dysfunction-associated steatohepatitis.