In fact, the more the balance in the stromal tumor microenvironment post NACT shifted in favor of CD8+ over FOXP3+ TILs, the better the survival (test for trend, p = 0.01), such that with a cutoff of ≥ 10, a high stromal CD8+/FOXP3 post NACT was associated with a significant improvement in both PFS (HR =  0.48; median: 19 vs. 31mo, p = 0.005, Fig. 5b) and OS (HR = 0.49; median: 37 vs. 51mo, p = 0.03, Fig. 5c). This evidence concerns the gene FOXP3 and neoplasm.