Overall, the median of CD8+/FOXP3+ ratios increased significantly post NACT in the stromal (p = < 0.0001) and intra-epithelial compartments (p = 0.0007) as well as the median of intra-epithelial CD3+/FOXP3+ ratios (p = 0.006) favoring anti-tumor immunity. Here, CD8A is linked to neoplasm.