Furthermore, it was found that NLRP3 and caspase-1 expression in rats was decreased by adenovirus-Angiopoietin-1 treatment, reducing the levels of IL-1b, IL-18 and IL-33 in both serum and bronchoalveolar lavage fluid samples from phosgene-induced adenovirus-Angiopoietin-1-treated rats with ALI [24]. This evidence concerns the gene CASP1 and acute respiratory distress syndrome.