Moreover, RT-qPCR results revealed significantly upregulated NLRP3 and downregulated miR-7b in the lung tissues of mice with ALI when compared to the normal mice, while delivery of sh-MEG3 + miR-7b mimic induced higher miR-7b expression and lower NLRP3 expression (Figure 5D). The gene discussed is MEG3; the disease is acute respiratory distress syndrome.