Infection of PMA‐treated THP‐1 shSAMHD1 cells with HIV‐1 GFP that had been produced in the presence of increasing doses of LPV led to a virus and LPV dose‐dependent increase in the expression of ISGs CXCL‐10, IFIT‐2 and MxA at the mRNA level (Fig 1D–F), and CXCL‐10 protein secretion (Fig 1G). Here, MX1 is linked to infection.