SAMHD1 and infection: SAMHD1‐depleted THP‐1 cells (herein referred to as THP‐1 shSAMHD1 cells) remained fully competent for innate immune sensing and produced interferon‐stimulated genes (ISGs) and inflammatory chemokines including CXCL‐10, IFIT‐2 (also known as ISG54) and CXCL‐2 in response to a range of stimuli, including transfection of herring testis DNA (HT‐DNA), exposure to 2′3′‐cGAMP and infection by Sendai virus (Appendix Fig S1C–E).