SP1 and infection: As with HIV‐1 GFP produced in the presence of PIs, infection of PMA‐treated THP‐1 shSAMHD1 cells with the HIV‐1 GFP ∆CA‐SP1 mutants led to a ∆CA‐SP1 dose‐dependent increase in the expression of CXCL‐10 (Fig 2C) and MxA mRNA (Fig 2D), and CXCL‐10 at the protein level (Fig 2E).