MEF2C and epilepsy: These two modules were of interest due to significant enrichment of several major categories of genes (Figure 2A): (1) DEGs in neuronal Mef2c conditional KO cortex (Mef2c-cKOEmx1; Harrington et al., 2016), (2) excitatory and inhibitory neuronal genes, (3) genes downregulated in SD and RS, and (4) genes involved in synaptic function, epilepsy and cognitive pathologies including autism (Figure 2D).