GSK3B and myotonic dystrophy type 1: However, inhibition of GSK3β prevents muscle atrophy in mice (Shen et al. 2017) and guinea pigs (Verhees et al. 2013), and it further prevents development of myotonic dystrophy type 1 (DM1), eventually leading to skeletal muscle being characterized by higher fiber density, and normal fiber size (Wei et al. 2018).