TGFB1 and idiopathic pulmonary fibrosis: Senescent cells secrete various mediators (e.g., IL-1, IL-6, IL-10, TGF-β), which promote fibrosis and may play a role in the epithelial mesenchymal transition in UIP, which may be brought on by dysfunctional autophagy [6, 8, 38, 45, 52, 53].