Of the three further articles that explored the impact of NLC on disease activity (per DAS28), Muñoz-Fernández et al. found that there were no significant differences in RA disease activity with NLC versus PLC at 12-month follow-up (mean DAS28 of 2.7 vs. 2.8, respectively; P = 0.274) [33]. Here, HSPG2 is linked to rheumatoid arthritis.