MBP and schizophrenia: Studies in adult postmortem samples using electron microscopy and histochemistry suggest structural changes in oligodendroglia cells that produce the myelin sheath [10, 11], an atrophy of axons, abnormalities of the myelin sheath surrounding [12, 13], a reduction in myelin basic protein (MBP) in the anterior frontal cortex in cases of schizophrenia [14], and a decrease in MBP expression in the gray matter of the frontal cortex of patients with schizophrenia [15].