PPARGC1A and colorectal carcinoma: Additionally, function assays verified that MPC1 overexpression could attenuate the migration and invasion capacities of CRC cells in vitro and MPC1 knockdown could enhance the metastasis capacity in vivo. And existing studies have revealed that the MPC1 was participated in metastatic dissemination of PGC1α-transduced cholangiocarcinoma through elevating reactive oxygen species (ROS) production [10].