TP53 and colonic neoplasm: The results indicated that the six DDR genes were downregulated in colon cancer cells with AURKA overexpression but upregulated when knocking down AURKA in colon cancer cells (Figures 4(c) and 4(d)), which implied that AURKA increased the chemosensitivity of colon cancer cells to DNA damage-inducing drugs by inducing the degradation of TP53 and then decreasing the expression of DDR genes.