Further studies have indicated that circCCDC66 contains multiple different binding sites of miRNA, and the overexpression of circCCDC66 acts as a miRNA sponge to interfere with miRNA-33b and miR-93, inhibiting its binding to downstream target genes, leading to high expression of downstream target genes, thereby increasing the level of MYC protein and promoting the proliferation, invasion, and metastasis of colon cancer [30]. The gene discussed is MYC; the disease is colonic neoplasm.