In those hub genes identified in PPI analysis, the protein Titin encoded by the gene TTN is a key component in the assembly and functioning of vertebrate striated muscles, and a mutation in the TTN gene can cause familial dilated cardiomyopathy (DCM) [55], centronuclear myopathy [56] and is involved in progressive muscular dystrophies during early human development [57]. Here, TTN is linked to familial dilated cardiomyopathy.