CCNB1 and posterior cortical atrophy: Finally, the levels of Bax, cleaved Caspase-3/-8/-9, and cleaved PARP-1 are upregulated, while the levels of XIAP, Cyclin B1, and Bcl-2 are downregulated, and cell growth inhibition and apoptosis are induced by the treatment of phloretin in PCa cells in vitro and in vivo.