MAP2K1 and posterior cortical atrophy: From the western blot data, we also found that phloretin downregulated the levels of p-PI3K, p-AKT(S473), p-AKT(T308), p-C-RAF, p-MEK, and p-ERK1/2 in a concentration-dependent manner, while there is almost no effect on the total protein levels of PI3K, AKT, RAF, MEK1/2, and ERK1/2 in PCa cells (Figures 4(a) and 4(b)).