In exploring the molecular mechanism of phloretin-induced cell growth inhibition, cell cycle arrest, and apoptosis in PCa cells, we found that phloretin treatment substantially downregulated the autophosphorylation levels of EGFR at Y1173, but not the total protein level of EGFR (Figure 4(a)), suggesting the activity of EGFR was inhibited by phloretin (it is the same as isorhapontigenin treatment in PCa cells we reported previously [35]). This evidence concerns the gene EGFR and posterior cortical atrophy.