SP3 and neoplasm: In addition, the western blot data of PC-3-transplanted tumor tissues demonstrated that the protein levels of Sp1, Sp3/4, Survivin, and Cyclin D1 were decreased, while the protein levels of c-Caspase 3 and c-PARP-1 were increased in the HD and PC groups (compared with the NC and LD groups) (Figure 7(e)).