Immunohistochemistry (IHC) data showed that the levels of Ki-67 (marker of cell proliferation), Sp1, Sp3/4, and Survivin in the cells of PC-3-transplanted tumor tissues were all decreased with the treatment of phloretin, and these protein levels in the tumor cells of the HD group were almost the same as those of the PC group (5-FU treatment) (Figure 7(d)). This evidence concerns the gene SP1 and neoplasm.