Inhibition of these pathways further inhibited the activation of Sp1 and subsequently resulted in the downregulation of Sp3/4 proteins, cell growth, and antiapoptosis-related proteins (including Cyclin D1, Cyclin B1, Bcl-2, Survivin, AR, VEGF, and XIAP) and the upregulation of cell apoptosis-related proteins (including c-Caspase 3, c-Caspase 8, c-Caspase 9, and c-PARP-1), and finally resulted in cell growth inhibition and apoptosis in prostate cancer cells both in vitro and in vivo (Figure 7(f)). Here, VEGFA is linked to Familial prostate cancer.