Among the top 20 KEGG pathway entries, the differentially expressed mRNAs participate in TNF signaling, rheumatoid arthritis, inflammatory, Staphylococcus aureus infection, systemic lupus erythematosus, graft-vs-host disease, allograft rejection, intestinal immune network for IgA production, type I diabetes mellitus, herpes simplex infection, toll-like receptor signaling pathway, and NF-κB signaling pathway among others (Figure 4F). The gene discussed is TNF; the disease is systemic lupus erythematosus.