Mutations in SF3B1 can lead to alternative splicing events for multiple genes and are found in several cancers, including uveal (frequency of 10–20%) (Harbour et al., 2013; Martin et al., 2013, p. 1; Dono et al., 2014, p. 1), mucosal (Newell et al., 2019; Nassar and Tan, 2020), and cutaneous melanoma (Kong et al., 2014). Here, SF3B1 is linked to cancer.