DDX3X and cancer: DDX3X gene encodes an ATP-dependent DEAD-box RNA helicase frequently altered in various human cancers, including melanomas (Stransky et al., 2011; Wang L. et al., 2011; Kandoth et al., 2013; Bol et al., 2015; The Cancer Genome Atlas Network, 2015; Ojha et al., 2015; Hayward et al., 2017).