Despite MITF acts together with many transcription factors as SOX10, YY1, TFAP2A, LEF1, RB1, IRF4, and PAX3 (Seberg et al., 2017), its activity level determines the phenotype adopted by melanoma cells, whether invasive, proliferative, or differentiated according to the MITF rheostat model (Goding, 2011). This evidence concerns the gene RB1 and melanoma.