First described in glioma (Balss et al., 2008, p. 1; Parsons et al., 2008; Yan et al., 2009, p. 2), mutations in IDH1 and IDH2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial) were described in several cancers, including melanoma (Lopez et al., 2010). The gene discussed is IDH1; the disease is melanoma.