Interestingly, Wong SQ et al. found that melanoma tumors harboring RQCD1/CNOT9 P131L mutation were associated with increased thickness, head and neck and upper limb location, lentigo maligna melanoma subtype, and BRAF V600K but not V600E or NRAS Q61 mutations (Wong et al., 2015). This evidence concerns the gene CNOT9 and melanoma.