BRAF and melanoma: In 2015, The Cancer Genome Atlas analyzed 333 cutaneous melanoma samples by integrating integrated multi-level genomic analyses, namely WES and low-pass WGS, transcriptome sequencing including miRNA, protein expression, and classified melanoma in four major molecular subtypes: mutant BRAF, mutant RAS, mutant NF1 and triple wild-type (The Cancer Genome Atlas Network, 2015).