TACC1 and neoplasm: TACC1 mutations were first reported in a WES study of 121 melanoma tumor/normal pairs reporting five novel melanoma candidate genes, including TACC1, with a frequency of 7% which was confirmed in a further similar study of 25 metastatic/germline pairs (Berger et al., 2012; Hodis et al., 2012) (Supplementary Figure S8C).