BRAF and melanoma: RASA2 mutations co-occurred in NF1 mutant melanomas that were BRAF-RAS wild type, in a WES study of 213 melanoma samples (62 cell lines and 151 melanomas); 12.2% (26/212) of melanomas were NF1-mutant/BRAF-RAS-wild-type and nine of them harbored co-mutations in RASA2 (2 nonsense and 3 R551C) (Krauthammer et al., 2015).