GALC and Krabbe disease: Overall, our results show that both NPCs and HSPCs secrete consistent amounts of the GALC precursor protein (80 kDa), which can be recaptured by deficient GLD neurons/glial cells and, in the lysosome, can be activated by cleavage and assembling of the 50 and 30 kDa forms into the active multimeric enzyme (Hill et al., 2018).