GSTM1 and sickle cell disease: Hemoglobinopathies are the most common genetic disorder wordlwide, and include the Sickle Cell Disease (SCD) (Schnog et al., 2004; Rees et al., 2010; Kato et al., 2018), caused by structural changes in the globins chains of hemoglobin (Hb), and the thalassemia syndromes (Weatherall and Clegg, 2001a; Thein, 2013) that are disorders of globin chains expression (Schechter, 2008; Steinberg, 2008; Kohne, 2011).