Except for Sortilin, members of the VPS10 family possess several domains between the VPS10 subunit and the transmembrane helix; two polycystic kidney disease (PKD) domains and a SorCS membrane proximal (SoMP) domain for the three SorCS subfamily members, an epidermal growth factor-like (EGF), 11 low-density lipoprotein receptor type A repeats (LA) and six fibronectin type III (FN3) domains for the fifth family member SorLA. This evidence concerns the gene EGF and polycystic kidney disease.