FLCN and renal cell carcinoma: The loss of FLCN is linked with an activity of the AKT/mTORC pathway (Cash et al., 2011; Schmidt and Linehan, 2018), leading to Birt–Hogg–Dubé autosomal dominant syndrome and increasing the risk of hybrid oncocytic renal cell carcinoma (RCC) and pulmonary cysts (Kapitsinou and Haase, 2008; Bonora et al., 2015).