Intracerebroventricular infusion of Ang-(1-7) for 2 weeks also prevented cognitive decline and decrease the expression of hippocampal phospho-tau, amyloid-ß oligomer, and both soluble (Aβ 1-42) and insoluble (Aβ 1-40) ß- amyloid peptide in an AD-like rat model resulting from streptozotocin-induced diabetes. The gene discussed is MAPT; the disease is Alzheimer disease.