PTGS2 and hyperuricemia: To elucidate the contribution of miR-214 to the pathogenesis of UA-induced apoptosis in endothelial cells, we observed the circulating levels of miR-214 in the patients with hyperuricemia and in endothelial cells challenged with UA, investigated the function of miR-214 and COX-2 in UA-induced endothelial apoptosis, and examined the regulation of miR-214 on COX-2 in the present study.