Ibrahim et al. demonstrated that proapoptotic lipotoxic signaling triggered by mixed lineage kinase 3 (MLK3) induces the release of proinflammatory Hep-EVs enriched in potent C-X-C motif chemokine ligand 10 (CXCL10) that, in turn, lead to monocyte-derived macrophages chemotaxis to the liver and may activate KCs during NASH progression (50). The gene discussed is MAP3K11; the disease is metabolic dysfunction-associated steatohepatitis.