MKI67 and neoplasm: In a large study by Zaidi et al. including 1,006 patients, the authors developed and validated a prediction model that assigns points according to the presence of symptoms (1 point), tumor diameter (≥2 cm: 2 points), Ki67 (<3, 3–20, and >20%, respectively, 0, 1, and 6 points), and presence of lymph nodal metastasis (1 point) (22).