CLOCK and metabolic dysfunction-associated steatotic liver disease: In a study involving mice with diet-induced obesity and NAFLD, time-restricted feeding (feeding only for 8 h during dark phase) for HFD-fed mice, which consumed the same amount calories as that of HFD ad libitum mice, altered hepatic clock genes that are related to key enzymes for glucose and lipid metabolism in the liver, thus decreasing hepatic fat accumulation (142).