In multiple myeloma, the antagonistic effect of a form of RNA called MALAT1 (metastasis-associated lung adenocarcinoma transcript1) will lead to the accumulation of ubiquitin proteins, induce ERS, up-regulate the expression of ER sensor proteins such as GRP78, activate autophagy, and induce apoptosis (Figure 1; Table 1) (16, 34). Here, HSPA5 is linked to plasma cell myeloma.