Our multivariate Cox regression analysis showed that decreased E2 and progesterone levels are risk factors, independent from other parameters including age, SBP, DBP, diabetes, hypertension, prolactin, luteinizing hormone, testosterone, and follicle-stimulating hormone, and that they might be predictors of 30-day mortality in older women undergoing hip fracture surgery. The gene discussed is PRL; the disease is diabetes mellitus.