Furthermore, among those with an HIV-1 infection, the APRIL levels were positively associated with both the CD4+ T-cell count (r = 0.2918, p = 0.0225) and CD4/CD8 ratio (r = 0.3236; p = 0.0132) but not the CD8+ T-cell count (Figures 3C–E). This evidence concerns the gene CD4 and HIV-1 infection.