RUFY3 seems therefore to have different axogenic functions in brain (Mori et al., 2007; Honda et al., 2017b) and not surprisingly, roles for RUFY3 in amyotrophic lateral sclerosis (Arosio et al., 2016), major depressive disorder (Aberg et al., 2018) and AD (Zelaya et al., 2015) have been reported. This evidence concerns the gene RUFY3 and amyotrophic lateral sclerosis.