This group have also found that tumour-to-stroma ratio (TSR), which represents the percentage of malignant cell component relative to the stroma in the tumor tissue, have an impact on infiltrated DC phenotype: high TSR was associated with elevated PD-L1 expression on mature DCs (CD11c+HLA-DRhigh) infiltrating in ovarian tumor tissue (MacGregor et al., 2019b). This evidence concerns the gene CD274 and neoplasm.