Another study investigated the correlation between tumor-infiltrating lymphocytes (TILs) and malignant diversity in HGSOC samples, where the authors found epithelial CD8+ TILs were negatively associated with tumor clonal heterogeneity, suggesting neoantigen-specific depletion of tumor clones and spatial antigen-specific T cell tracking of tumors (Zhang et al., 2018). This evidence concerns the gene CD8A and neoplasm.