CD274 and cancer: Brahmer et al. (2012) reported a clinical trial regarding the activity of BMS-936559 in advanced cancer. A total of 200 patients were enrolled, 17 of whom were ovarian cancer patients. The results demonstrated that at a 10 mg/kg dose, 1 ovarian cancer patient achieved a partial response, and 3 ovarian cancer patients achieved stable disease. Avelumab, a human anti-PD-L1 antibody, could specifically bind to PD-L1 and block the links with PD-1 (Heery et al., 2017). Disis et al. (2019) described a cohort study on the effect of avelumab in refractory or relapsed ovarian cancer.