Effective T cell activation by DCs require DC maturation, a process happens after DC exposing to antigen, characterized by increased membrane expression of MHC and co-stimulatory molecules (CD80, CD86, CD40) (Bol et al., 2016; Bhatia et al., 2019), alteration of chemokine receptors to favor DC lymph node (LN) migration (Drakes and Stiff, 2018); mature DCs produce cytokines that favor Th1 (anti-tumor) immunity. Here, HLA-C is linked to neoplasm.