IL4 and neoplasm: In a mouse model of metastatic ovarian cancer, Goossens et al. (2019) used Gene Ontology (GO) enrichment analysis and found that at a later time after tumor inoculation (day 21), there was an up-regulation of cholesterol metabolic gene clusters in TAMs, resulting in membrane-cholesterol efflux and depletion of lipid rafts from TAMs, leading to IL-4-mediated immune-suppressive TAM reprogramming.