S1PR3 and neoplasm: Our new findings in the present study demonstrate that upregulation of miR-9-2 locus in tumor ECs is significantly associated with downregulation of S1P1 and S1P3, and further validate that S1P1 acts as a bona fide target for miR-9, and the downregulation of S1P1 contributes to EC migration, invasion, and angiogenesis.