The CD34 labeled vessels tended to increase with S1P1 inhibition, but the combined inhibition of S1P1 and VEGF pathways reduced blood flow in tumor, increased tumor cell apoptosis, and inhibited the tumor CD34 positive vessels in clear cell renal cell carcinoma tumor models (Fischl et al., 2019). The gene discussed is S1PR1; the disease is clear cell renal carcinoma.