LRP6 and Alzheimer disease: Considering that recent studies propose a role for LRP6 in Wnt signaling, particularly in dendritic synapse structure and long-term potentiation (LTP) in AD (Liu C.C. et al., 2014), is possible to suggest that a dysregulation of the more upstream Wnt signaling components might be related with both aging and age-related pathological conditions of the CNS in O. degus.