Recently, some researchers have found that the dentate gyrus granule cells of TLE and other animal models of epilepsy form abnormal mossy fiber synapses, which indicates that the recruitment of AMPAR (especially GluA1 and GluA2 subunits) is induced (Joshi et al., 2017; Joshi and Kapur, 2018). Here, GRIA2 is linked to epilepsy.