Consistent with these findings, BAG5 was found to promote dopaminergic neuron death in the substantia nigra in rodent models of PD (Kalia et al., 2004) and interact with other PD relevant proteins including LRRK2, PINK1, and DJ-1 (Beilina et al., 2014; Wang et al., 2014; Qin et al., 2017; Tan et al., 2019; De Snoo et al., 2019). This evidence concerns the gene PINK1 and Parkinson disease.