NLRP3 and Hepatic fibrosis: NLRP3 inflammasome is involved in the fibrosis process of various organs or tissue, such as kidney fibrosis (Lorenz et al., 2014), pulmonary fibrosis (Hosseinian et al., 2015), liver fibrosis (Alegre et al., 2017), and cardiac fibrosis (Sandanger et al., 2013; Luo et al., 2014; Li F. et al., 2018).