CREBBP and CHARGE syndrome: Searching the literature for OB hypoplasia/aplasia in these conditions unveiled a large number of studies involving CHARGE syndrome (Lin et al., 1990; Harvey et al., 1991; Pinto et al., 2005), but only a couple of human reports on RSTS and KLFS (Ajmone et al., 2018; Ciaccio et al., 2019).