Pdgf is further supported as an effective activator of HSCs through the fibrotic role of Agrin (Agrn), a secreted proteoglycan induced by Pdgf-induced HSC activation in HCC in Diethyl nitrosamine (DEN)-induced HCC Sprague Dawley rat model (Lv et al., 2017). The gene discussed is AGRN; the disease is hepatocellular carcinoma.