Moreover, attenuation of TSP1 activated TGFB can be achieved with a TSP1 antagonist peptide and has been shown to decrease liver fibrosis in a dimethyl-nitrosamine liver fibrosis model (Li et al., 2017; Murphy-Ullrich and Suto, 2018), demonstrating the importance of this relationship. Here, THBS1 is linked to Hepatic fibrosis.