Quercetin induces apoptosis by inhibiting different signaling pathways including the MAPK/Erk, PI3K/Akt, and NF-κB signaling pathways (Zhang et al., 2015; Xavier et al., 2019); it also inhibits the migration and invasion of CRC cells via regulating the toll-like receptor 4/NF-κB signaling pathway (Han et al., 2016). This evidence concerns the gene TLR4 and colorectal carcinoma.